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QSB Seminar Series

Date: 
September 2, 2016 - 1:30pm

Dr. James Hurley, UC Berkeley

HIV is an efficient and deadly pathogen because its tiny proteome is so efficient in hijacking cellular machinery. This will be illustrated with four vignettes. In the first, I will show how the HIV Nef protein hijacks clathrin coated vesicle trafficking to evade immune defenses. In the second, a new structure will be presented that shows how the HIV Tat protein and TAR RNA work together to drive transcription of the provirus. In the third, an unexpected role for bulk tRNAs in the cytosol is revealed in ensuring that new viruses package the correct dimeric and un-spliced RNA genome. In the fourth, HIV Gag hijacks the ESCRTs to drive the release of new viruses. These examples illustrate both the frightening “ingenuity” of this rapidly evolving pathogen, and its vulnerabilities. 

Location

Location: 
Classroom and Office Building 1 267

Contact Information

Name: 
Patti LiWang
Title: 
Professor
Department: 
School of Natural Sciences, Molecular Cell Biology
Address: 
5200 North Lake Rd.
Merced, CA 95343
United States
Address: 
5200 North Lake Rd.
Merced, CA 95343
United States