Rachel S. Friedman, University of Colorado Medical School
The destruction of the insulin-producing pancreatic islets that causes type 1 diabetes is largely caused by T cells. However, T cells do not act independently to drive disease. We focus on understanding environmental factors and immune cell interactions that activate or inhibit the pathogenic T cells that damage the islets. Our long term goal is therapeutically enhance existing tolerance pathways and disrupt pathogenic pathways in the islets to treat type 1 diabetes.