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Seminar in Molecular Cell Biology

Date: 
March 16, 2016 - 1:00pm to 3:00pm

Of mice and men: HSC transplantation fails to fully regenerate the immune system

Dr. Eliver Ghosen

The current paradigm posits that a single hematopoietic stem cell (HSC) is capable of regenerating all components of the immune system. However, our recent studies in murine HSC transplantation have challenged this broadly accepted paradigm and establishes a novel concept of HSC-independent hematopoiesis. In essence, we showed that long-term (LT)-HSCs, purified from fetal liver and adult bone marrow, selectively fail to regenerate B-1a, a subset of tissue primitive lymphocytes required for protection against Pneumonia, Influenza, and other infectious diseases. Hence, our studies define a lineage of tissue B cells (B-1a) that originates prior to and independent of the HSC and overtly challenge the current paradigm that HSC transplantation regenerates all components of the immune system.

Location

Location: 
Science and Engineering 1 Building, Room 270K

Contact Information

Name: 
Jennifer Manilay
Title: 
Associate Professor
Department: 
Molecular Cell Biology, School of Natural Sciences
Address: 
5200 North Lake Rd.
Merced, CA 95343
United States
Address: 
5200 North Lake Rd.
Merced, CA 95343
United States