Professor Nobile's research is directed toward understanding the molecular and mechanistic basis of microbial communities. Her lab is interested in investigating how transcriptional networks underlie the regulation of gene expression during biofilm development. Much of this work is carried out in the species Candida albicans, the most prevalent fungal pathogen of humans. The lab is also beginning to study interspecies interactions between different fungal and bacterial species. Questions that the lab is currently pursuing include: How are microbial communities regulated? How are microbial communities built? How are their unique and specialized properties maintained? How have microbial communities evolved?