Professor Ye's research is focused on developing the nanoscale surface chemistry needed to manipulate and measure biomolecules and analogous systems. The nanoscale arrangements of biomolecules, such as proteins and DNA, underlie a wide spectrum of biological functions. Yet our ability to measure and control biomolecules at the nanoscale and single molecule level remains very limited. His group is using and developing sophisticated nanoscience tools to position and measure single molecules with nanometer resolution, dynamically activate the functions of individual biomolecules on surfaces, and develop artificial analogs of biological motors. The greatly improved understanding and control of biomolecules at the nanoscale have implications in unraveling key biological functions, creating artificial functional bimolecular structures, and developing ultra-sensitive biosensors.