Tim Clark, University of San Diego
Selective C–H bond functionalization of arenes continues to be an important avenue of research as a method to efficiently synthesize biologically relevant, substituted arenes from simple precursors. Conversion of unreactive C–H bonds to synthetically useful C–B bonds allows for production of value-added fine chemicals based on the versatility of the C–B bond in synthesis. Our group has developed the phosphine-directed C–H borylation, which provides a diverse group of ambiphilic phosphine boronates. The use of an unusual cationic iridium pre-catalyst was found to be key to a broad substrate scope. These compounds have potential as organocatalysts and bifunctional ligands. The versatile C–B bond can also be used to access a wide range of functionalized phosphines. Progress in each of these areas will be discussed.
Flyer File: clark_timothy_ccb_flyer.pdf