Roberta Pelanda, University of Colorado
Among the numbers of diverse B cells that are generated daily in the bone marrow, only half enter the primary B cell repertoire to patrol the body, and these are the ones that are less
self-reactive. Autoreactive B cells that bind self-antigen with high avidity in the bone marrow undergo mechanisms of central tolerance that prevent their entry into the peripheral B cell population. These mechanisms are breached in many autoimmune patients increasing their risk for B cell-mediated autoimmune diseases. But what are the biochemical pathways that regulate the entry of bone marrow B cells into the periphery? How do these pathways operate? And what are the consequences when these pathways are altered? This seminar will present our findings from studies of mice that generate autoreactive or nonautoreactive B cells, as well as humanized mice with human B cells.
Flyer File: pelanda_roberta_qsb_flyer.pdf