The ins and outs of Cannabinoid receptor function
Dr. Guillermo Yudowski
G protein-coupled receptors (GPCRs) can elicit multiple waves of signaling which are mediated by heterotrimeric G proteins and the scaffold protein b-arrestin. Our laboratory is specifically interested in understanding and controlling, the signaling wave mediated by b-arrestins. We combine live cell imaging techniques with biochemical and in vivo studies to understand the mechanisms and physiological roles of barrestin mediated signaling. Our results also identify new strategies to modulate GPCR signaling.