January 27, 2017 - 8:00pm
Dr. Lanning, California State University, Los Angeles
Abstract:
Mitochondrial dysfunction is associated with many pathologies including cancer, neurodegenerative diseases, cardiovascular disease, and mitochondrial diseases. However, in many cases, the distinct mechanisms by which mitochondrial dysfunction promotes these diseases remain unknown, and up to 20% of the mitochondrial proteome remains functionally uncharacterized. We screened ~1,000 mitochondrial proteins for their contributions to maintaining cellular energy homeostasis, and identified a mitochondrial adenylate kinase which significantly regulates ATP levels, AMPK/mTOR signaling, and cellular redox homeostasis.
Flyer File
Location
Classroom and Office Building 2 170
Contact Information
School of Natural Sciences
