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Cell Biology, Developmental Biology, and Genetics

Miriam Barlow


Evolution of bacteria

Predicting the evolution of antibiotic resistance

Testing evolutionary theory
(209) 228-4174
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Michael D. Cleary
Associate Professor

Professor Cleary is interested in how complex tissues develop from relatively small populations of stem cells. Nervous system development in the fruit fly, Drosophila melanogaster, provides an excellent model system for studying this process. His lab focuses on how Drosophila neural stem cells, called neuroblasts, which produce the diversity of cell types found in the nervous system. His primary aim is to understand:

  • How cell fate decisions are temporally regulated, so that distinct cell types are made at specific times during development
  • How mitotic activity is regulated, so that neuroblasts stop and start dividing at the proper time
  • How cell fate information is passed from a neuroblast to its progeny and the role of chromatin remodeling factors and other transcription factors in this process

His research team uses the many powerful molecular and genetic techniques available for Drosophila research to address these questions, with the ultimate goal of identifying mechanisms that are conserved in human stem cells.
(209) 228-4554
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Gabrielle Loots Gabriela Loots
Associate Adjunct Professor
  • Developmental and comparative genomics
  • Transcriptional regulation
  • Transgenic technologies
  • Skeletal and limb development
  • Bone and cartilage tissue engineering
  • Genetics of bone disease — Sclerosteosis and Van Buchem Disease
(925) 423-0923
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Jennifer O. Manilay
Associate Professor

Professor Manilay is a developmental immunologist, with research interest in the mechanisms that control cell fate decisions in the immune system. Her current topic of study is the development of T lymphocytes, important components of immune defense against pathogens.
(209) 228-4175
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Nestor Oviedo
Associate Professor
  • Tissue regeneration
  • Stem cells
  • Cancer
  • Planarian biology
(209) 228-4541
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Katrina Hoyer
Assistant Professor

Immunological tolerance and autoimmune disease

Cellular and molecular interplay between lymphocytes and dendritic cells
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Fabian Filipp
Assistant Professor

Systems biology of cancer metabolism:
Stable isotope fluxomics in response to nutrition, metabolic disease, and drugs; methods development in NMR spectroscopy, structural, and chemical biology; structure, dynamics, and function of human lipogenesis machinery in human cancer progression
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Axel Visel
Adjunct Professor
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Anna Beaudin
Assistant Professor

Defining immune development from discrete hematopoietic progenitors

Specification and function of developmentally-restricted immune cells

Long-term impact of developmental perturbation on immune function and disease susceptibility
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Xuecai Ge
Assistant Professor

The Ge lab is interested in understanding molecular mechanisms of neurodevelopment and its related diseases. We focus on the developing cerebral cortex and cerebellum, and study how different cell signaling pathways integrate to govern neural stem cell proliferation and differentiation. Specifically, we aim to understand: 

  • How signaling pathways are integrated at the cilium, the antenna of the cell, to control cell behaviors;
  • How the molecular signaling pathways interact with each other to control the cell proliferation and cell fate determination in the developing brain; and
  • How to apply what we learn from cultured cells and animal models to clarify the pathogenesis of neural developmental disorders and pediatric brain tumors.
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Stephanie Woo
Assistant Professor

Endoderm development and epithelial morphogenesis in zebrafish.
(209) 228-4030
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Chris Amemiya
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